Cloud Security Best Practices & Compliance is a comprehensive course aimed at professionals responsible for protecting cloud-based infrastructures, services, and data. The course starts with an overview of shared responsibility models across major cloud providers (AWS, Azure, GCP) and explains the differences between IaaS, PaaS, and SaaS security approaches. Learners are introduced to key security principles such as defense in depth, least privilege access, zero trust architecture, and secure by design. Core topics include identity and access management (IAM), multi-factor authentication (MFA), role-based access control (RBAC), and secrets management using services like AWS Secrets Manager and Azure Key Vault. The course also covers encryption techniques for data at rest and in transit, key management systems (KMS), and secure APIs. Learners explore logging, monitoring, and alerting with tools like CloudTrail, GuardDuty, Azure Sentinel, and GCP Security Command Center. Compliance frameworks such as GDPR, HIPAA, SOC 2, ISO 27001, and FedRAMP are discussed, along with strategies for aligning cloud deployments to regulatory requirements. Real-world case studies and threat modeling exercises help students apply concepts to protect against misconfigurations, insider threats, and data breaches. By the end, learners will be equipped to build secure, compliant, and resilient cloud architectures suitable for enterprise environments.